Abstract: Intentional forgetting refers that individuals intentionally forgot useless or outdated information, which is important for human life and memory updating. In recent years, intentional forgetting research has become a hot topic, both domestic and abroad research findings about intentional forgetting become richer, but system introduction and conclusion about brain mechanism of intentional forgetting is lacked. Therefore, based on related findings, we respectively introduced the brain mechanism of directed forgetting and suppression forgetting. The brain mechanism of directed forgetting was mainly reflected in encoding and retrieval phase. In encoding phase, different instructions caused different brain activities, R (remembering) instruction caused activation of memory processing region, while F (forgetting) instruction caused activation of inhibitory region. These different brain activities supported attention inhibition theory of directed forgetting, which believed that directed forgetting was because participant actively inhibited rehearsing and processing of F item. In retrieval phase, different old/new effects existed between TBR-R (to be remembered-remembered) items and TBF-R (to be forgotten-remembered) items, the former were based on recollection, and the latter were based on familiarity. While TBF-F (to be forgotten-forgotten) items induced reversed old/new effects, which indicated that need to forget items was inhibited in retrieval phase, so retrieval inhibition is also an explanation of directed forgetting. In a word, the brain mechanism research of directed forgetting showed that directed forgetting is an active inhibition process, encoding inhibition and retrieval inhibition both play important role in directed forgetting. The brain mechanism of suppression forgetting mainly reflected in differences between think items and No think items. Think items and No think items respectively activated different brain areas, think items increased activation of hippocampus and other memory-related brain areas, while No think items increased activation of prefrontal cortex and reduced activation of hippocampus. The existing suppression forgetting explanation is prefrontal-hippocampus assumption, which considered that individuals will firstly induce activation of prefrontal cortex and subsequently inhibit activation of hippocampus so as to achieve the goal of inhibiting unwanted memory. Though the present review illustrated the brain mechanism of directed forgetting and suppression forgetting, there were still many problems to be solved. Future research should focus on：the brain mechanism differences of directed forgetting and suppression forgetting; the brain mechanism differences between memory inhibition and other psychological suppression; intentional forgetting of traumatic experience and mental illness individuals; plasticity research of memory control network.

Key words: intentional forgetting, directed forgetting, suppression forgetting, brain mechanism

摘要： 有意遗忘是指个体主动忘记无用和过时的信息，本质是记忆的主动抑制，包括定向遗忘和压抑遗忘。在定向遗忘中，记忆抑制既发生在编码阶段也发生在提取阶段，脑机制研究支持编码抑制理论和提取抑制理论；在压抑遗忘中，think和No-think所激活的脑区不同，No-think引起前额区域的激活增强和海马的激活减弱。未来应开展定向遗忘和压抑遗忘的脑机制差异研究，注重记忆抑制和其他心理活动抑制之间的差异研究，关注创伤个体的有意遗忘研究，拓展记忆控制神经网络的可塑性研究。

关键词: 有意遗忘, 定向遗忘, 压抑遗忘, 脑机制