Abstract: The ability of preventing unwanted memory from invading awareness is important for mental health. Using the Think/No-Think paradigm, previous studies have proved that individuals can forget episodic memory by direct suppressing them repeatedly. Our unwanted memories come from multiple sensory channels in daily life. However, most researches adopted visual materials, and few researches considered other sensory domains. In the present study, we used auditory-visual materials to investigate the cross-modal memory inhibition, and separated the control instruction and memory cue to test the anticipatory effect. Thirty-one healthy participants who were native speakers of Chinese were recruited from Southwest University, 19 of whom were female. And their average age is 20 (SD=1.73). The stimuli consisted of 64 randomly combined sound-word pairs, and 16 of them were used for practice. The sound materials with 2.5s long were taken from common sounds in daily life, such as dog barking and motorcycle launching. The word materials were nouns with two Chinese characters. The procedure included learning phase, pre-test, Think/No-Think phase and post-test phase. In the learning phase, the participants were required to first passively memorize and then actively learn with feedback. In the Think/No-Think phase, the memory cue was played for 2.5s, followed by a 2.5s blank. The Think/No-Think control instruction was presented with 1s before the memory cue (Hanslmayr et al., 2009). There were 12 repetitions for each trial, and EEG was recorded during the Think/No-think phase. Both the same probe and the independent probe were tested after the Think/No-think phase. We found that the recall performance of suppression condition is significantly worse than that of baseline condition in the independent probe rather than the same probe. Event-related potentials (ERPs) revealed two main findings: 1) in the last 6 repetitions, negativity in the right frontal-central area is enhanced by No-think instruction compared with Think instruction before memory cue presented (300~1000ms); and the difference between two conditions is due to the negative enhancement under the No-think instruction instead of the Think instruction from the first repetition set to the second repetition set; 2) during 500~1500 ms after memory cue presented, positive potential in the central-parietal area related to No-think items is less than that related to Think items, while activity in the right frontal area is reversed; and compared to unlearned items, learned items with No-think instruction induce more positive activity in the right frontal area, while there is no significant difference between learned and unlearned items under Think instruction. The results demonstrated that the active forgetting effect can be achieved on target memory itself with the auditory-visual cross-modal condition. And we verified there was an expected processing before memory suppression if the task instruction was presented in advance. In addition, we found that the continuous inhibition control process under the condition of memory suppression triggers the late positive potentials in the right front. Further researches will need to explore the sources of anticipation and the late inhibition control components, and adopt a variety of sensory materials on the study of cross-modal memory suppression to promote the clinical applicability of the active forgetting effect.

Key words: active forgetting, memory suppression, cross-modal, LPP, anticipation

摘要： 基于视觉通道的研究表明，人们可以通过主动抑制记忆提取而实现遗忘。但目前对跨通道的主动遗忘尚缺乏探讨。本研究以声音为记忆线索，以文字为目标记忆，采用“想/不想”范式，探究主动遗忘在跨视听通道条件下的可行性。结果发现，“不想”条件下目标记忆的回忆率低于基线条件，主动遗忘发生。此外，我们通过分离任务指令和记忆线索的呈现时间，在中央区域的ERP中发现了记忆抑制的期待效应；并在额叶观察到“不想”条件下晚期正成分的增强，反映了持续的抑制控制过程。本研究不但验证了跨视听通道主动遗忘的可能性，而且第一次从ERPs角度分离了跨通道遗忘相关的期待加工和抑制控制过程。

关键词: 主动遗忘, 记忆抑制, 跨通道, LPP, 期待效应